Summary: N6-methyladenosine (m6A) methyltransferase Mettl3 is involved in conventional T cell immunity; however, its role in innate immune cells remains largely unknown.Here, we show that Mettl3 intrinsically regulates invariant natural killer T (iNKT) cell development and function in an m6A-dependent click here manner.Conditional ablation of Mettl
Background and aims: Attention deficit hyperactivity disorder (ADHD) is one 30x24x24 wall cabinet of the most common psychiatric disorders with a worldwide prevalence of 5%.The prevalence is even higher among school age children ranging from 8% to 12%.ADHD is predominantly childhood-onset disorder and can persist into adolescence and adulthood to i
Abstract Autophagy is a widespread physiological process in the body, which also protects the host by degrading invading pathogens and harmful substances during pathological conditions.Nevertheless, Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis, has evolved strategies to subvert autophagy by modulating microRNA (miRNA) expre
ABSTRACT Coccidioides posadasii is a pathogenic fungus that causes coccidioidomycosis in many arid regions of the Americas.One of these regions is bordered by the Caribbean Sea, and the surrounding landscape may play an important role in the dispersion of C.posadasii across South America through southeastern Mexico, Honduras, Guatemala, and soderha